Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared\nby electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and\ndissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II.\nTriethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers\nwere formulated to exert the synergistic effect on the drug-dissolution improvement. The composition\nand the electrospinning parameters were changed to select the fibrous sample of optimum fiber\ncharacteristics. To determine the morphology of the nanofibers, scanning electron microscopy was\nused. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC)\nwere applied for the solid-state characterization of the samples, while the drug release profile was\nfollowed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range\nof few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization\nof aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the\nselected ternary fiber composition (10 mg/g aceclofenac, 1% w/w triethanolamine, 15% w/w PVPK90)\nwere found to be suitable for obtaining orally dissolving webs of fast dissolution and potential\noral absorption.
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